The following events took place in 22 BBY.
- An Expedition to the Via Lactea Galaxy is started
- Ada Karr is sent to the Jedi Temple to train
- Fardonar War begins, with making it a "war inside a war" during the Clone Wars
- Yich goes to Kamino to get his new clone army
- Imbroglio Summit
- The task force to protect Tenochtitlan is established
- Sandyar Marek becomes Anakin Skywalker's apprentice
- Padmé Skywalker constructs her lightsaber on Ilum.
- The Catpire takes over Byss
- Jyuria Song is made a Jedi Knight
- Platinum squad is founded and later in the year, dissolved
- Ben Sunrunner(CC-1163) is deployed in the GAR
- MI5 rescued Sharkey and destroyed Finn Killifer's illegal cloning facility.
- The Clone Wars begins.
- The Cytebb is built on Foerost.
- Republic Civilian War Effort Alliance is formed.
- Triong Re'e is constructed on Ord Zathuun.
- Bombing of the Republic Senate building, a lone Separatist sympathiser manages to hide a remotely-detonated Thermal detonator on a Senate building shuttle, the bomb causes large damage to the shuttle arrival area, the bomber hacks into the Senate's communications and anonymously takes credit for the attack, and threatens more bombings until the Republic Senate ends the war and makes peace with the Confederacy, however he is caught by the Jedi whilst trying to rig another bomb but the Jedi are forced to kill him when he refuses to surrender, saying he would rather die as a martyr to the cause for freedom of the Confederacy than have his name and ideologies tarnished by a lengthy prison sentence for terrorism.
- The Union President Richard Williams makes the Proclamation of Self-Determination, in which he declares that the priority of the Union is to bring self-determination to all peoples of Earth, the proclamation angers the people of the Zarkan Kingdom, whose empire covers 1/7 of the Earth, feeling betrayed by the Union the vast majority of the people of the Zarkan Kingdom call for the secession of the Zarkan Kingdom and Empire from the Union of Earth States.
- Battle of Imbroglio
- Battle of Hi Syier
- First Battle of Byss
- First Battle of Kamino
- First Battle of Ord Zathuun
- Fondor shipyard assault
- Battle of Quas Killam
- Darth Edel on Coruscant
- Hurc Chaso on an unknown planet
- Mary on Kashyyyk
- Renna Mooncylle on Tatooine
- Gaw Gaw
- Dandor Gidven on Geonosis
- Finnar Aquan on Geonosis
- Yohan on Geonosis
- Thousands of Gungans in the Battle of Tristan
- Rhadé Sarasvati Nalanda on Imbroglio
- Tolan Hing on Bespin
- Mika Anaki on Dantooine
- Rex Heaven on Nadiem
- Sharkey's clone squad (all nine members) on Nadiem
- R4-D4 on Nadiem
- Camili Boont assassinated on the Dradan homeworld by 3X-AK2R
- Yarus on Coruscant
- Numerous Senate Guards and civilians during the Bombing of the Senate Building's shuttle arrival area.
- The Separatist sympathiser who conducted the bombing.
25 BBY 24 BBY 23 BBY - 22 BBY - 21 BBY 20 BBY 19 BBY